一、动脉内灌注:即通过导管将药物直接注入肿瘤供应动脉。使局部组织药物浓度更高,而全身药量减少,其局部效应及毒性决定于肿瘤类型、肿瘤血管状态、药物与肿瘤及正常细胞之间的接触时间、药物浓度和作用机理以及局部内环境(PH、PO_2和PCO_2),动脉内灌注方法的改进及有关问题: First, intra-arterial infusion: the drug is injected directly into the tumor through the catheter to supply the artery. The local tissue drug concentration is higher and the systemic drug dose is reduced. The local effects and toxicity depend on the tumor type, tumor vascular status, contact time between drug and tumor and normal cells, drug concentration and mechanism of action, and local internal environment ( PH, PO_2, and PCO_2) Improvements in intraarterial infusion methods and related issues: