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目的探讨35~60岁农村妇女人乳头瘤病毒(HPV)感染状况及其与宫颈病变的关系。方法选择2013年6月-2016年6月大竹县5 000例35~60岁已婚妇女进行宫颈薄层液基细胞学、宫颈脱落细胞HPV-DNA以及阴道镜检查。结果5 000例受检者中,HPV感染总阳性率为29.66%(1 483/5 000)。受检者中无宫颈病变4 104例,宫颈鳞状化生245例,慢性宫颈炎442例,CINⅠ101例,CINⅡ64例,CINⅢ44例;宫颈癌前病变妇女HPV感染率分别为67.33%、78.13%和86.36%,明显高于其他受检者,差异有统计学意义(P<0.05);35~40岁、41~50岁和51~60岁组HPV感染率分别为29.84%、30.04%和29.33%,各年龄段比较,差异无统计学意义(P>0.05);首次性生活年龄≤20岁妇女HPV感染率为37.57%,明显高于其他年龄段组,差异有统计学意义(P<0.05)。结论大竹县35~60岁农村妇女HPV感染与宫颈病变和初次性生活年龄有关。
Objective To investigate the status of human papillomavirus (HPV) infection in rural women aged 35 ~ 60 and its relationship with cervical lesions. Methods From June 2013 to June 2016, 5 000 married women aged 35-60 years in Dazu County were tested for cervical smear-based cytology, HPV-DNA in cervical exfoliated cells and colposcopy. Results Among 5 000 subjects, the total positive rate of HPV infection was 29.66% (1 483/5 000). There were 4,104 cases of cervical lesions, 245 cases of cervical squamous cell carcinoma, 442 cases of chronic cervicitis, 101 cases of CINⅠ, 64 cases of CINⅡ and 44 cases of CINⅢ. The HPV infection rates of women with cervical precancerous lesions were 67.33% and 78.13%, respectively 86.36%, which was significantly higher than other subjects (P <0.05). The HPV infection rates were 29.84%, 30.04% and 29.33% in 35 ~ 40, 41 ~ 50 and 51 ~ (P> 0.05). The HPV infection rate of the first sex life less than or equal to 20 years old was 37.57%, which was significantly higher than other age groups (P <0.05), the difference was statistically significant . Conclusion HPV infection in rural women aged 35 ~ 60 in Dazhu County is related to cervical lesions and the age of first-time sexual life.