论文部分内容阅读
苯妥英钠是治疗癫癎、心律失常的常用药物之一。由于本品碱性强(pH11.7),空腹时口服对胃有较强的刺激性。饮食后或与治疗胃病药物同时服用,可减轻胃的不适感。但是,空腹时胃液pH值与饮食或服用胃药后不同pH值的改变是否会影响苯妥英钠的释放度?为此笔者对苯妥英钠在不同pH介质中体外释放度进行实验,供临床用药时参考。材料与仪器苯妥英钠片(100mg糖衣片,江苏省盐城制药厂,批号850402-1),放免盒~(125)I-DPH(北京空军总院);FT-663自动计算~(125)I放免测量仪,78-X片剂四用测定仪(上海黄
Phenytoin sodium is one of the commonly used drugs for the treatment of epilepsy and arrhythmia. Since this product is alkaline (pH11.7), fasting oral strong stomach irritation. After eating or with the treatment of stomach medication at the same time, can reduce the stomach discomfort. However, the fasting pH value of gastric juice and diet or taking different changes in gastric pH after the drug will affect the release of phenytoin sodium? To this end, phenytoin sodium in different pH in vitro release rate of experiments for clinical reference . Materials and equipment Phenytoin sodium tablets (100mg sugar-coated tablets, Yancheng Pharmaceutical Factory of Jiangsu Province, batch number 850402-1), put the box-free ~ (125) I-DPH (Beijing Air Force General Hospital); FT-663 automatic calculation of ~ Measuring instrument, 78-X tablet four with a detector (Shanghai Huang