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采用LC-MS/MS法研究炙甘草配伍对附子水煎液中双酯型乌头类生物碱的含量和离体肠吸收的影响。以生附子水煎液和生附子炙甘草药对水煎液为研究对象,考察两种水煎液中以乌头碱、新乌头碱和次乌头碱为代表的双酯型乌头类生物碱的含量差异。并通过离体外翻肠囊模型,考察炙甘草配伍对三者在不同肠段吸收的影响。结果表明炙甘草配伍附子在显著降低游离的双酯型乌头类生物碱的含量和肠道吸收率的同时,还可以促使各肠段对乌头类生物碱无差异吸收,达到减毒缓释的作用。
The effect of Baked Licorice Mixture on the content of Aconite aconitum alkaloids and intestinal absorption in vitro of Fuzi Decoction was studied by LC-MS / MS. In this paper, the decoction of raw monkshood and raw herb aconite Sunburn licorice were taken as the research object to investigate the effects of aconitine, mesaconitine and hypaconitine in the two decoctions Alkaloids content differences. And exocytosis by exocytosis model to investigate the compatibility of Zhigancao three in different intestinal absorption. The results showed that the combination of Zhigancao aconite significantly reduce free Aconitum alkaloids content and intestinal absorption rate, but also can promote the intestinal segments Aconitine alkaloids no difference in absorption, to achieve sustained release of attenuated Role.