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注射氨甲喋呤(MTX)治疗异位妊娠的临床应用非常普遍,但由于治疗时间长,患者对多次注射难以接受,且存在药物的毒性作用问题。口服MTX的生物利用度为80％～85％,用量为60mg/m~2(注射剂量为50mg/m~ 2)。为评价口服MTX治疗异位妊娠的作用,对22例确诊为输卵管妊娠者进行研究,通过血hCG值、血浆孕酮测定联合阴道B超确诊。对异位妊娠包块大小<4cm(无胎心)或<3.5cm(有胎心)的情况稳定的患者,给予口服MTX治疗,用标准的25mg MTX片剂,按60mg/m~2分2次间隔2h给药。给药当天为第1d,分别在第4
The clinical application of methotrexate (MTX) in the treatment of ectopic pregnancy is very common, but due to the long duration of treatment, the patient is refractory to multiple injections and has the problem of toxic effects of the drug. The bioavailability of oral MTX is 80% ~ 85%, the dosage of 60mg / m ~ 2 (injection dose of 50mg / m ~ 2). To evaluate the role of oral MTX in the treatment of ectopic pregnancy, 22 patients diagnosed with tubal pregnancy were studied, and blood hCG values and plasma progesterone were measured in combination with vaginal B-ultrasound. Patients with stable ectopic pregnancy <4 cm (no fetal heart rate) or <3.5 cm (with fetal heart) were given oral MTX treatment with standard 25 mg MTX tablets at 60 mg / m ~ 2 Interval 2h administration. The first day of administration, respectively, in the first 4