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目的 观察脑梗死患者血清载脂蛋白 (ApoH)水平与血脂的相关性 ,探讨ApoH与脑梗死的关系。方法 :放免法测定ApoH血清水平 ,ELISA法测定Lp(a)水平 ,免疫比浊法测定ApoA - 1和ApoB ,酶法测定HDL、LDL、TG、TC。结果 脑梗死患者血清ApoH水平显著高于卒中危险因素对照组和正常对照组 (P <0 0 5 ) ,且ApoH的水平与TC、LDL呈正相关 (γ =0 5 2 ,P <0 0 1,γ =0 49,P <0 0 5 ) ,与TG、Lp(a)无相关性。结论 脑梗死患者血清ApoH血清水平与TC、LDL相关 ,ApoH可能通过干扰脂质代谢 ,在脑梗死的发生发展过程中起一定的作用。
Objective To observe the correlation between serum apolipoprotein (ApoH) level and blood fat in patients with cerebral infarction and to explore the relationship between ApoH and cerebral infarction. Methods: ApoH serum levels were determined by radioimmunoassay, Lp (a) levels by ELISA, ApoA - 1 and ApoB by immunoturbidimetric assay, and HDL, LDL, TG and TC by enzymatic assay. Results Serum levels of ApoH in patients with cerebral infarction were significantly higher than those in stroke control group and normal control group (P <0.05), and the level of ApoH was positively correlated with TC and LDL (γ = 0.52, P <0.01, γ = 0 49, P <0 05), no correlation with TG and Lp (a). Conclusions Serum ApoH serum levels in patients with cerebral infarction are related to TC and LDL. ApoH may play a role in the development of cerebral infarction by interfering with lipid metabolism.