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作者报告美国乳腺癌药物辅助手术研究组临床协作研究的两项初步结果。从1958年开始的研究工作,通过十年随访业已阐明乳腺癌术后如腋下淋巴结阳性,生存率为24、9%,淋巴结数目为1～3个的37.5%,超过4个阳性的只有13.4%。就是淋巴结阴性的病人也有1/4治疗失败。因此,从1972年夏37个研究单位开始了一项新的研究,观察在典型或改良的根治术后长期应用L-苯丙氨酸氮芥(L-PAM)的结果。截至1974年9月,给予
The authors report two preliminary results of a clinical collaboration study of the US Breast Cancer Drug-Assisted Surgery Study Group. From the beginning of the 1958 research work, after 10 years of follow-up, it has been clarified that postoperative breast cancer such as axillary lymph nodes is positive, the survival rate is 24, 9%, the number of lymph nodes is 1 to 3, 37.5%, and more than 4 positives are only 13.4. %. That is, a quarter of patients with negative lymph nodes also have failed treatment. Therefore, a new study was started in 37 research institutes in the summer of 1972 to observe the long-term use of L-phenylalanine mustard (L-PAM) after radical or modified radical resection. As of September 1974, given