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目的 研究整合素αVβ3在人胆管癌组织中的表达及其与胆管癌的临床病理关系。方法 采用免疫组织化学方法检测47例人胆管癌组织及正常癌旁胆管组织中整合素αVβ3的表达。结果 整合素αVβ3表达于人胆管癌细胞及胆管癌组织中的新生血管细胞,47例标本均呈阳性表达,其表达强度与是否伴有肿瘤转移有显著差异(P <0 0 5 ) ,而与性别、癌组织分化程度无关。结论 整合素αVβ3可能在胆管癌细胞的恶性生物学行为中具有重要的作用,检测整合素αVβ3表达可以作为胆管癌预后判断的依据之一。
Objective To investigate the expression of integrin αVβ3 in human cholangiocarcinoma and its clinicopathological relationship with cholangiocarcinoma. Methods Immunohistochemistry was used to detect the expression of integrin αVβ3 in 47 cases of human cholangiocarcinoma and adjacent normal bile duct tissue. Results The expression of integrin αVβ3 in human cholangiocarcinoma and cholangiocarcinoma was positive. The positive expression of integrin αVβ3 in 47 cholangiocarcinoma and cholangiocarcinoma tissues was significantly different from that in tumor metastasis (P <0.05) Gender, cancer tissue differentiation has nothing to do. Conclusion Integrin αVβ3 may play an important role in the malignant biological behavior of cholangiocarcinoma cells. The detection of integrin αVβ3 expression may be used as a basis for the prognosis of cholangiocarcinoma.