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目的观察散发型克-雅病脑电图波型的发展与变化,揭示临床、电生理和病理机制间的关系。方法对3例伴快速进展性神经功能障碍及与克-雅病相一致的实验资料的患者,进行多次常规脑电图的记录观察。结果观察到与其不同阶段相对应的脑电图特征,典型表现为周期性尖慢复合波。结论人类朊蛋白疾病的明确诊断须脑病理活检,脑电图在此类疾病的诊断及临床病程判断中仍是最重要的检查之一。
Objective To observe the development and changes of sporadic Creutzfeldt-Jakob disease EEG patterns and to reveal the relationship between clinical, electrophysiological and pathological mechanisms. Methods A total of 3 patients with fast-acting neurological dysfunction and experimental data consistent with Creutzfeldt-Jakob disease were enrolled and recorded on a number of routine EEG records. Results The EEG features corresponding to different stages of the EEG were observed. The typical manifestation was cyclical sharp slow complex. Conclusion The diagnosis of human prion diseases must be biopsy of brain pathology. EEG is still one of the most important examinations in the diagnosis and clinical course judgment of such diseases.