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微卫星稳定性作为评价DNA错配修复系统(MMR)的功能标记,可作为Ⅱ期和Ⅲ期结直肠癌患者辅助治疗的风险评估有效工具。全文从错配修复基因/微卫星不稳定性与结直肠癌发生及其在Ⅱ/Ⅲ期结肠癌化疗辅助治疗中的应用方面进行综述。
Microsatellite stability as a functional marker for evaluating DNA mismatch repair system (MMR) can be used as an effective tool for risk assessment in adjuvant treatment of patients with stage II and III colorectal cancer. This review summarizes the mismatch repair gene / microsatellite instability and the occurrence of colorectal cancer and its application in the adjuvant chemotherapy of chemotherapy for stage Ⅱ / Ⅲ colon cancer.