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目的 观察大鼠全脑缺血后经脑室注射胰岛素对海马区神经元病理形态学改变的影响 ,探讨胰岛素对海马区神经元迟发性死亡的作用 .方法 利用改良四血管闭塞法 ,建立大鼠全脑缺血模型 .缺血再灌注后即刻经脑室注 1U胰岛素 ,于缺血再灌注后 1,3,5和 7d断头取脑 ,光镜下计数海马区正常神经元 .结果 缺血再灌注后 3,5及 7d治疗组鼠海马 CA1区正常神经元计数为 1(6 8.6± 10 .9) ,(133.5±10 .5 ) ,(10 5 .6± 10 .1) ,缺血组则为 (87.4± 5 .1) ,(4 5 .4±6 .1) ,(10 .5± 3.4) .两组比较存在显著差异 (P <0 .0 1) .结论 胰岛素对缺再性脑损伤具有中枢直接保护作用 ,且这种保护作用可减轻海马区神经元的迟发性死亡
Objective To observe the effects of insulin injected into the hippocampus by intracerebroventricular (icv) injection of insulin on the pathological changes of neurons in hippocampus after global cerebral ischemia in rats and to explore the effect of insulin on the neuronal death in the hippocampus.Methods The rats were established by modified four vessel occlusion The model of global cerebral ischemia was established by intracerebroventricular injection of 1U insulin immediately after ischemia-reperfusion, and the brains were sacrificed at 1, 3, 5 and 7 days after ischemia-reperfusion and the normal neurons in the hippocampus were counted under light microscope.Results The number of normal neurons in the hippocampal CA1 area of the rats in the three, five and seven days after the perfusion group was 1 (6 8.6 ± 10.9), (133.5 ± 10.5) and (105.6 ± 10.1), respectively (87.4 ± 5 .1), (45.4 ± 6 .1) and (10.5 ± 3.4), respectively, there was significant difference between the two groups (P <0.01) .Conclusion The effect of insulin on recanalization Brain damage has a central direct protective effect, and this protective effect can reduce delayed neuronal death in the hippocampus