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目的:比较单一外用与外用联合窄谱中波紫外线(NB-UVB)光疗治疗轻度斑块状银屑病的疗效、安全性、复发情况及治疗经济学.方法:采用随机对照临床试验,共纳入123例轻度斑块状银屑病患者,随机分为单一外用治疗组和外用联合光疗组,患者银屑病皮损面积和严重程度指数(PASI)积分下降达90％(PASI 90)时即进入维持治疗,分别于第6、12、24周评价疗效,并于第24周评价治疗经济学.结果:共86例患者完成24周治疗.在第6周时,单一外用治疗组22.50％患者达到PASI 75,外用联合光疗组为23.91％(P＞0.05).单一外用治疗组皮肤病生活质量指数(DLQI)分值较基线下降57.89％,外用联合光疗组下降52.39％(P＞0.05).在第12周时,单一外用治疗组40.00％的患者达到PASI 75,外用联合光疗组为45.70％(P＞0.05).第24周时,单一外用治疗组50％的患者达到PASI 75,外用联合光疗组为63.04％(P＞0.05).单一外用治疗组DLQI分值较基线下降64.60％,外用联合光疗组下降65.31％(P＞0.05).在24周的研究中,单一外用治疗组2例复发,外用联合光疗组3例复发.单一外用治疗组24周总费用平均为835.4元,外用联合光疗组为1894.23元.结论:单一外用疗法与外用药联合NB-UVB光疗均安全、有效、复发率低,且疗效相当.单一外用疗法更经济,适用于轻度斑块状银屑病的长期治疗.“,”Objective:To compare efficacy and cost of topical treatment versus topical treatment combined with narrowbandultraviolet B(NB-UVB) for mild plaque psoriasis.Methods:This was an open-label,randomized,multi-center,controlled study.123 patients with mild plaque psoriasis were randomized into two groups,receiving either topical treatment alone or combination of topical treatment and NB-UVB.When Patients achieved 90％ reduction in Psoriasis Area and Severity Index score(PASI 90),maintenance therapy was started.The efficacy was assessed at 6,12,and 24 weeks of treatment,respective ly.The cost was calculated after 24-week treatment.Results:86 patients completed 24-week study.At 6 weeks,22.50％ of patients in topical treatment group reached PASI 75,which was similar to that in combination therapy group (23.91％,P＞ 0.05).The Dermatology Life Quality Index(DLQI) scores in the two groups were decreased by 57.89％,and 52.39％,respec tively(P＞0.05).At 12 weeks,percentages of patients with PASI75 were also similar between topical treatment and combination group(40.00％ vs.45.70％,P＞0.05).Again,there were no significant differences in either the percentage of patients with PASI75 or percentage reduction in DLQI between topical treatment and combination group at 24 weeks(For PASI 75,50％ vs.63.04％,P＞0.05;For DLQI,64.60％ vs.65.31％,P＞0.05).Two patients in topical treatment group and three patients in combination group had recurrence.The total costs of 24-week treatment were 835.4 CNY in topical treatment group and 1894.23 CNY in combination group.Conclusions:Both topical treatment and combination therapy were safe and effective with low recurrence rate,while topical treatment costs less and is suitable for long-term treatment of mild plaque psoriasis.