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目的了解血浆IL-10和TNF-α的水平与患儿感染状态和预后的关系。方法将2002年1月~2004年1月收住院的患儿157例,分为败血症组(72例),一般感染组(58例)和非感染组(27例),用ELISA法检测患儿血浆IL-10和TNF-α水平。结果败血症组的IL-10、TNF-α水平显著高于一般感染组和无感染组;血培养阳性和血培养阴性的败血症组之间IL-10、TNF-α水平差异无显著性;IL-10水平和IL-10/TNF-α的比值在恶化或死亡病例中显著升高。结论IL-10、TNF-α水平可以敏感地反映机体感染的情况及预测预后。
Objective To investigate the relationship between the levels of IL-10 and TNF-α in plasma and the infection status and prognosis in children. Methods A total of 157 children admitted to hospital from January 2002 to January 2004 were divided into sepsis group (72 cases), general infection group (58 cases) and non-infected group (27 cases) Plasma IL-10 and TNF-α levels. Results The levels of IL-10 and TNF-α in sepsis group were significantly higher than those in normal infection group and non-infected group. The levels of IL-10 and TNF-α in serum-positive and blood-negative sepsis groups were not significantly different. The ratio of 10 levels to IL-10 / TNF-α was significantly increased in cases of worsening or death. Conclusion The levels of IL-10 and TNF-α can sensitively reflect the status of the infection and predict the prognosis.