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自1793年Baille认识到酒精中毒与肝硬化的伴随关系后,人类和动物实验皆表明酗酒者发生肝脏损害的危险性随着饮酒量和时间呈正相关。酒精性肝脏损害通常分为三种临床类型:酒精性脂肪肝、酒精性肝炎和酒精性肝硬化。酒精性肝脏损害的特征性改变是肝细胞内出现酒精性透明蛋白或称Mallory小体。
Since Baille realized the relationship between alcoholism and cirrhosis in 1793, both human and animal experiments showed that the risk of liver damage in alcoholics was positively correlated with alcohol intake and time. Alcoholic liver damage is usually divided into three clinical categories: alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. A characteristic change in alcoholic liver damage is the appearance of alcohol-based opacity or Mallory bodies in hepatocytes.