恶性黑色素瘤是起源于神经嵴黑素细胞的高侵袭性皮肤黏膜肿瘤,具有易复发、发生转移早、预后差、死亡率高等特点.随着对基因组和蛋白组学相关领域肿瘤分子机制研究的不断深入,发现引起肿瘤的机制有多种,如基因突变、缺失及表观遗传学等.目前表现遗传学已成为研究基因表达调控的热点,它包括多种修饰途径,其中DNA甲基化是较常见且 Malignant melanoma is a highly invasive cutaneous mucosal tumor originating from neural crest melanocytes, which has the characteristics of easy recurrence, early metastasis, poor prognosis and high mortality.With the research on the molecular mechanisms of tumor in genomic and proteomic related fields In-depth and found that there are many mechanisms that cause tumors, such as gene mutations, deletions and epigenetics, etc .. The current performance of genetics has become the focus of study gene expression regulation, which includes a variety of ways in which DNA methylation is More common and