【摘 要】
：
In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine,and prepare metronidazole-decorated Ti,Ti substrates were pre-modified with dopamine (DA) coating,and metronidazole was subsequently imm
【机 构】
：
Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430060, China;The State Key La
【出 处】
：
武汉理工大学学报（材料科学版）（英文版）
论文部分内容阅读
In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine,and prepare metronidazole-decorated Ti,Ti substrates were pre-modified with dopamine (DA) coating,and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates.The prepared MET-decorated Ti interfaces were prepared for surface characterization tests:contacting angle measurements,scanning electron microscope,ATR-FTIR spectroscopy and in vitro anti-biofilm formation assay.Statistical tests were performed using by SPSS16.0.Contacting angle measurement,scanning electron microscopy,and ATR-FTIR spectroscopy confirmed the successful presence of MET grafted on the Ti surface.In addition,the MET-decorated Ti induced good in vitro antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria,respectively.The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.
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