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目的探讨2型糖尿病患者的无症状糖尿病周围神经病(ADPN)神经电生理损害的相关因素,为临床早期诊断、早期干预提供依据。方法 176例2型糖尿病患者根据有无神经传导速度异常分为ADPN组(32例)和No-DPN组(144例),对比分析相关临床资料并探讨ADPN神经电生理损害的相关因素。结果单因素分析显示:ADPN组糖尿病病程、体质指数、空腹血糖、糖化血红蛋白、尿素氮、肌酐、24 h尿蛋白和尿微量白蛋白、眼底动脉血管改变与No-DPN组比较,差异有统计学意义(P<0.05);多因素Logistic回归分析显示:糖尿病病程、体质指数、空腹血糖、糖化血红蛋白是ADPN神经电生理损害的独立相关因素。结论神经传导速度测定可作为ADPN的早期诊断依据,病程、体质指数、空腹血糖、糖化血红蛋白与ADPN密切相关,应尽早诊断与干预。
Objective To investigate the related factors of electrophysiological impairment of asymptomatic diabetic peripheral neuropathy (ADPN) in type 2 diabetic patients and provide basis for early clinical diagnosis and early intervention. Methods One hundred and sixty-six patients with type 2 diabetes mellitus (T2DM) were divided into ADPN group (n = 32) and No-DPN group (n = 144) according to the presence or absence of neurotransmitter. The related clinical data were analyzed and compared. Results The results of univariate analysis showed that the difference of course of diabetes mellitus, body mass index, fasting blood glucose, glycosylated hemoglobin, urea nitrogen, creatinine, 24 h urinary protein and urinary albumin and fundus arterial blood vessels in ADPN group were statistically different from No-DPN group (P <0.05). Multivariate Logistic regression analysis showed that duration of diabetes, body mass index, fasting blood glucose and glycosylated hemoglobin were independent correlates of electrophysiological damage to ADPN. Conclusion Nerve conduction velocity measurement can be used as an early diagnosis basis of ADPN. The course of disease, body mass index, fasting blood glucose and glycosylated hemoglobin are closely related to ADPN. Diagnosis and intervention should be done as soon as possible.