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目的考察甘遂醋制前后对癌性腹水模型大鼠泻水逐饮功效的差异。方法以癌性腹水模型大鼠为研究对象,呋塞米为阳性药,分组连续7 d ig生、醋甘遂粉末及醇提加水提物,考察其对大鼠尿量,腹水量,尿钠、钾、氯离子水平,尿液p H值,肾素-血管紧张素II-醛固酮系统(RAAS),抗利尿激素(ADH)水平的影响。结果与模型组比较,各给药组大鼠尿量显著增加(P<0.05、0.01);腹水量,尿钠、钾、氯离子水平,尿液p H值显著减少(P<0.01);血清肾素(PRA)、血管紧张素II(Ang II)、醛固酮(ALD)、ADH水平显著降低(P<0.05、0.01)。其中生、醋甘遂粉末给药功效最为显著,且两组间无显著性差异。结论生、醋甘遂均具显著的泻水逐饮功效,对癌性腹水模型大鼠有良好的症状改善作用。
Objective To investigate the difference of efficacy between water and drink by drinking water in rats with cancerous ascitic fluid model. Methods The ascites model rat was taken as the research object, and furosemide was used as positive drug. The rats in group A were treated with ig, kadsura powder and alcohol extract water for 7 consecutive days, and their effects on urinary output, , Potassium, chloride ion level, urine p H value, RAAS, ADH level. Results Compared with the model group, the urinary output of rats in each group was significantly increased (P <0.05, 0.01); the amount of ascites, urine sodium, potassium, chloride and urine p H decreased significantly PRA, Ang II, aldosterone and ADH were significantly decreased (P <0.05, 0.01). Among them, the efficacy of administration of konjac powder is the most significant, and no significant difference between the two groups. Conclusions Health, vinegar and kansui both have significant effect of catharsis and drinking, and have good symptom improvement effect on cancerous ascites model rats.