嗜酸性粒细胞在呼吸道、肺组织局部浸润募集是支气管哮喘的特征性改变。嗜酸性粒细胞抗凋亡与促凋亡机制的失衡是导致这一改变的根本原因。其中抗凋亡因素包括白细胞介素类、TNF-α家族、CC趋化细胞因子、类脂质介质等,促凋亡因素包括生长因子类、细胞表面分子及其配体等。各种因素以不同的机制达到抗凋亡和促凋亡的作用,从而组成了复杂的调控网络,进一步影响支气管哮喘的发病。 Eosinophils in the respiratory tract, lung tissue is a local infiltration of bronchial asthma characteristic changes. The imbalance between eosinophil anti-apoptotic and pro-apoptotic mechanisms is the underlying cause of this change. Anti-apoptotic factors include interleukins, TNF-α family, CC chemotactic cytokines, lipid-like mediators, etc. The pro-apoptotic factors include growth factors, cell surface molecules and their ligands. A variety of factors in different mechanisms to achieve anti-apoptosis and apoptosis, which formed a complex regulatory network, and further affect the incidence of bronchial asthma.