使用左旋多巴治疗帕金森氏病所伴随的主要问题就是所谓的“开关”现象,表现为病入迅速交替出现的多动性与不动性,但其与给药时间无明显关联。应用本品治疗10年之后,50％以上的患者会出现这种波动。曾有从药物动力学和药效学效应两方面对此现象作出解释。药物动力学的因素是与进入脑组织中 The main problem associated with the use of levodopa in the treatment of Parkinson’s disease is the so-called “switch” phenomenon, which manifests itself in the rapid onset of hyperactivity and immobility, but not significantly related to the time of administration. After applying this product for 10 years, more than 50% of patients will experience this kind of fluctuation. This phenomenon has been explained both in pharmacokinetics and pharmacodynamic effects. Pharmacokinetic factors are associated with entering the brain tissue