传统认为多发性硬化(MS)病灶多在视神经、脊髓、脑干及脑室周围白质中;近来的研究显示病变也可出现在灰质中,尤其在大脑皮层中。关于大脑皮层病灶的特性、发病机制及临床意义仅有少量的研究报告。作者使用MRI技术对病人进行了系列研究,并对死后病人脑标本进行了MRI与神经病理学 Traditionally, multiple sclerosis (MS) lesions are found in the optic nerve, spinal cord, brain stem and periventricular white matter; recent studies have shown that lesions can also occur in the gray matter, especially in the cerebral cortex. About the characteristics of cerebral cortex lesions, the pathogenesis and clinical significance of only a small amount of research reports. The authors performed a series of patient studies using MRI techniques and performed MRI and neuropathology on post-mortem brain samples