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目的 探讨急、慢性白血病、恶性淋巴瘤患者血清铜蓝蛋白 CER(ceruloplasm in)水平变化及临床意义。方法 用免疫化学全自动分析仪全自动散色比浊法测定白血病 90例、恶性淋巴瘤 32例、良性血液病 5 1例及正常人 44例的血清铜蓝蛋白 CER值。结果 急性白血病组及恶性淋巴瘤组患者血清 CER测定值均较正常对照组及良性血液病组明显增高 (P<0 .0 0 1和 P<0 .0 1) ,血清 CER在急淋组和急非淋组间无显著性差异 (P>0 .0 5 ) ,急性白血病及恶性淋巴瘤达完全缓解后血清 CER值接近正常对照组 (P>0 .0 5 ) ,急性白血病组比慢性白血病组血清CER值明显增高 (P<0 .0 5 ) ,而良性血液病组血清 CER值接近正常对照组 (P>0 .0 5 )。结论 血清 CER对急性白血病及恶性淋巴瘤的辅助诊断、疗效的观察、预后的判断有一定的价值。
Objective To investigate the changes and clinical significance of ceruloplasm in patients with acute and chronic leukemia and malignant lymphoma. Methods Serum ceruloplasmin CER value was measured by automated immunochemical autoassay with turbidimetry in 90 cases of leukemia, 32 cases of malignant lymphoma, 51 cases of benign blood diseases and 44 cases of normal subjects. Results Serum levels of CER in acute leukemia group and malignant lymphoma group were significantly higher than those in normal control group and benign blood group (P <0.01 and P <0.01, respectively) There was no significant difference between acute leprosy group (P> 0.05), acute leukemia and malignant lymphoma reached complete remission serum CER value close to normal control group (P> 0.05), acute leukemia group than chronic leukemia Serum CER was significantly higher (P <0.05) in patients with benign hematological diseases than in healthy controls (P> 0.05). Conclusions Serum CER has certain value in the diagnosis of acute leukemia and malignant lymphoma, the observation of curative effect and the prognosis.