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本文使用弥散张量成像及白质纤维束追踪技术构建和分析了15名脑性瘫痪患儿和30名正常婴儿大脑的白质脑网络,发现脑性瘫痪患儿和正常婴儿的白质脑网络都具有“小世界”属性,但患儿的最短路径长度明显变长,而标准聚类系数、全局效率和局部效率明显下降。此外,我们还发现左脑楔叶、左右脑楔前叶以及左脑扣带回后部是婴儿白质脑网络的核心节点,患儿白质脑网络的部分节点存在异常,且异常节点多集中于颞叶、枕叶和顶叶。本文结果表明脑性瘫痪婴儿的白质脑网络已经出现紊乱的现象,这为我们进一步研究脑性瘫痪儿童的发病机制提供了帮助。
In this paper, diffusion tensor imaging and white matter fiber tracking technology was used to construct and analyze the white matter brain network of 15 children with cerebral palsy and 30 normal infants. It was found that white matter brain network of children with cerebral palsy and normal infants had “Small world” attribute, but the length of the shortest path of children significantly longer, and the standard clustering coefficient, global efficiency and local efficiency decreased significantly. In addition, we also found that the left wedge, the left and right wedge anterior lobe, and the left cingulate gyrus back are the core nodes of the white matter network in infants. Some nodes in the white matter brain of children are abnormal, and the abnormal nodes are mostly concentrated in the temporal Leaves, occipital lobe and parietal lobe. The results of this paper show that the white matter brain network in infants with cerebral palsy has been disturbed, which is helpful for further studying the pathogenesis of cerebral palsy children.