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目的:观察分析不同人群中TTV(transfusion transmitted virus)感染状况及相关临床意义。方法:在TTVORF1设计引物,建立巢式聚合酶链反应,检测不同人群中血清TTV DNA,并对比观察肝炎病人的临床表现。结果:29例健康人群,27例职业献血员,56例乙型肝炎,31例丙型肝炎和47例非甲～非庚型肝炎患者中,TTV DNA阳性率分别为6.9％、3.7％、23.2％、25.8％和42.6％。3种肝炎病人中,TTV DNA阳性和阴性组间4项主要临床指标无显著差异。结论:健康人群和职业献血员存在TTV健康携带者。非甲～非庚型肝炎患者TTV感染率最高。乙型和丙型肝炎患者重叠TTV感染较常见。3种肝炎病人中,合并TTV感染组与非感染组临床表现无明显差异。TTV的致病性尚待深入研究。
Objective: To observe and analyze the status of transfusion transmitted virus (TTV) in different population and its clinical significance. Methods: Primers were designed in TTVORF1 to establish nested polymerase chain reaction to detect serum TTV DNA in different populations. The clinical manifestations of patients with hepatitis were compared. Results: The positive rates of TTV DNA were 6.9%, 3.7%, 23.2%, respectively in 29 healthy people, 27 professional blood donors, 56 hepatitis B patients, 31 hepatitis C patients and 47 non-hepatitis- %, 25.8% and 42.6%. Among the three kinds of hepatitis patients, there were no significant differences among the four main clinical indexes of TTV DNA positive and negative groups. Conclusion: TTV healthy carriers exist in healthy population and professional blood donors. Non-hepatitis A non-hepatitis T patients with the highest infection rate. Patients with hepatitis B and C overlap TTV infection is more common. Among the three kinds of hepatitis patients, there was no significant difference in the clinical manifestations of patients with and without TTV infection. TTV pathogenicity yet to be further studied.