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Aims: To assess the validity of QTc dispersion to cardiac autonomic nervous function status. Method and results: Prospective comparisons of QTc dispersion measurements in 77 neurally mediated cardiac syncope(NMCS) patients (29 boys, 48 girls, mean age 13.4±0.78) were evaluated. Head-up tilt test(HUT)-was positive in 38 patients and negative in 39 patients. QTc dispersion was significantly higher early morning and late night in HUT-positive group compared with HUT-negative group(p< 0.001). Although there was a circadian rhythm in HUTpositive group, there was no change on the QTc dispersion within a day in the HUT-negative group. QTc dispersion in the HUT-positive group was high in accordance with their high sympathetic nervous stimulation. Moreover, QTc dispersion was higher during late night and early morning than the rest of the day. Conclusion: These results may explain why the HUT positive patients usually have their syncope attacks early in the morning. Additionaly, we can use QTc dispersion measurement as a new noninvasive electrocardiographic test to evaluate cardiac sympathetic nervous system in NMCS.
Method and results: Prospective comparisons of QTc dispersion measurements in 77 neurally-mediated cardiac syncope (NMCS) patients (29 boys, 48 girls, mean age 13.4 ± 0.78) were (HUT) -was positive in 38 patients and negative in 39 patients. QTc dispersion was significantly higher early and late in HUT-positive group compared with HUT-negative group (p <0.001). there was a circadian rhythm in HUTpositive group, there was no change on QTc dispersion within a day in the HUT-negative group. QTc dispersion in the HUT-positive group was high in accordance with their high sympathetic nervous stimulation. was higher during late night and early morning than the rest of the day. Conclusion: These results may explain why the HUT positive patients usually have their syncope attacks early in the morning. Additionaly, we can use QTc dispersion measurement as a new noninvasive electrocardiographic test to evaluate cardiac sympathetic nervous system in NMCS.