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目的探讨门冬胰岛素30注射液联合吡格列酮治疗老年2型糖尿病的疗效。方法选取2010年10月—2012年10月厦门市第三医院内分泌科门诊治疗40例老年2型糖尿病患者,均单独应用胰岛素治疗3个月以上,所有患者随机分为观察组和对照组,每组20例,观察组采用门冬胰岛素30注射液联合吡格列酮治疗,对照组仅给予门冬胰岛素30注射液治疗。治疗3个月后检测并比较两组患者治疗前后空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(Hb A1c)、丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、尿素氮(BUN)、肌酐(Cr)、甘油三酯(TG)、血红蛋白(Hb)及胰岛素用量等项目。结果观察组治疗后FPG、2 h PG、Hb A1c、TG及胰岛素用量均明显低于对照组(P<0.01)。结论门冬胰岛素30注射液联合吡格列酮治疗可有效控制老年2型糖尿病患者血糖和血脂水平,减少了胰岛素用量。
Objective To investigate the curative effect of insulin aspart 30 and pioglitazone on senile type 2 diabetes. Methods From October 2010 to October 2012, 40 elderly patients with type 2 diabetes mellitus were treated in Department of Endocrinology, the Third Hospital of Xiamen. All patients were treated with insulin alone for more than 3 months. All patients were randomly divided into observation group and control group. Group, 20 cases. The observation group was treated with insulin aspart 30 injection combined with pioglitazone. The control group was given insulin aspart 30 injection only. After 3 months of treatment, fasting blood glucose (FPG), 2-hour postprandial blood glucose (2h PG), Hb A1c, ALT, aspartate AST, BUN, Cr, TG, Hb, insulin dosage and so on. Results The levels of FPG, 2 h PG, Hb A1c, TG and insulin in the observation group were significantly lower than those in the control group (P <0.01). Conclusion Aspartic insulin 30 injection combined with pioglitazone can effectively control blood sugar and blood lipid levels in elderly patients with type 2 diabetes and reduce insulin dosage.