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Most reported fluorescent probes have limitations in practical applications in living systems due to the strong autofluorescence background,construction of probes with near-infrared(NIR) fluorescence emission is an accessible approach for addressing this challenge.We here designed a NIR fluorescent probe for monitoring the endogenous production of H_2S in living cells.The designed probe showed significant NIR fluorescence turn-on response to H_2S with high selectivity,enabling the sensitive detection H_2S.Importantly,the probe could be applied in monitoring the endogenous production of H_2S in raw 264.7 macrophages.This study showed that fluvastatin can promote the activity of cystathionineγ-lyase(CSE) for generation H_2S.
Most reported fluorescent probes have limitations in practical applications in living systems due to the strong autofluorescence background, construction of probes with near-infrared (NIR) fluorescence emission is an accessible approach for addressing this challenge. We designed a NIR fluorescent probe for monitoring the endogenous production of H_2S in living cells. The designed probe showed significant NIR fluorescence turn-on response to H_2S with high selectivity, enabling the sensitive detection H_2S. Implantantly, the probe could be applied in monitoring the endogenous production of H_2S in raw 264.7 macrophages. This study showed that fluvastatin can promote the activity of cystathionine γ-lyase (CSE) for generation H_2S.