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Fas是一种重要的诱导细胞凋亡的死亡受体,在靶细胞表面相应配体FasL的激活下介导细胞凋亡。最近的研究揭示肝癌细胞通过表达FasL反击免疫系统,消除体内抗肿瘤T细胞,并且抵抗Fas/FasL系统介导的凋亡,从而使肿瘤成为机体的免疫豁免部位而逃逸免疫系统的攻击。本文就Fas/FasL系统
Fas is an important death receptor that induces apoptosis and mediates apoptosis under the activation of the corresponding ligand FasL on the surface of target cells. Recent studies have revealed that HCC cells attack the immune system through the expression of FasL, eliminate anti-tumor T cells in vivo, and resist Fas / FasL system-mediated apoptosis, thereby allowing the tumor to escape the immune system as an immune immunity site. This article on the Fas / FasL system