制备疟疾疫苗,进行疟疾有效免疫,以达到控制疟疾感染和流行,是当今防疟中期待解决的课题。体外培养疟原虫,做为疟疾抗原的来源,被认为系最好途径。许多学者设想在体外建立疟原虫孢子增殖期培养系统,试图获得由配子体发育成有免疫原性的子孢子,用以制备子孢子疫苗。为此,国内外对猴疟、鸟疟和鼠疟等动物疟原虫进行了许多研究。 The preparation of malaria vaccines for effective malaria immunization in order to control malaria infections and epidemics is an ongoing issue in the fight against malaria. In vitro culture of malaria parasite, as a source of malaria antigens, is considered the best way. Many scholars have envisaged the establishment of a culture system for the propagation of Plasmodium sporozoites in vitro in an attempt to obtain sporozoites that develop from gametophytes to be immunogenic for the preparation of sporozoite vaccines. To this end, many domestic and foreign studies on malaria parasites such as malaria, bird malaria and murine malaria have been carried out.