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目的观察坦索罗辛单药治疗BPH(良性前列腺增生症)导致的LUTS(下尿路症状)的临床疗效。方法门诊选择100例BPH患者,随机分成2组,试验组50例,服用盐酸坦索罗辛0.2mg,1次/d;对照组50例,同时服用非那雄胺5.0mg,1次/d,盐酸坦索罗辛0.2mg,1次/d,观察药物治疗效果,主要是下尿路症状的改善。结果 1个月内下尿路症状的有效改善为试验组49例(98%),对照组48例(96%),两组差异无统计学意义(P>0.05)。两组患者IPSS均≤13分,QOL为(3±1)分,Qmax均≤18ml/s,残余尿量测定均≤40ml,服药前后比较并有统计学意义(P≤0.05)。结论盐酸坦索罗辛单药治疗BPH导致的LUTS的临床疗效满意。
Objective To investigate the clinical efficacy of tamsulosin monotherapy in treating LUTS (lower urinary tract symptoms) caused by BPH (Benign Prostatic Hyperplasia). Methods 100 outpatients were selected BPH patients were randomly divided into two groups, the experimental group of 50 patients taking tamsulosin hydrochloride 0.2mg, 1 / d; control group of 50 patients, taking finasteride 5.0mg, 1 / d , Tamsulosin hydrochloride 0.2mg, 1 times / d, observe the effect of drug treatment, mainly the improvement of lower urinary tract symptoms. Results The effective improvement of lower urinary tract symptoms in one month was 49 cases (98%) in the experimental group and 48 cases (96%) in the control group, with no significant difference between the two groups (P> 0.05). The IPSS of both groups were ≤13 points, QOL was (3 ± 1) points, Qmax were all ≤18ml / s, residual urine volume was less than or equal to40ml, both before and after treatment were statistically significant (P≤0.05). Conclusion The clinical efficacy of tamsulosin hydrochloride monotherapy in the treatment of BPH-induced LUTS is satisfactory.