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应用抗ＣＤ４抗体（ａｎｔｉ－ＣＤ４）诱导移植耐受，治疗自身免疾病已引起人们的重视。ＣＤ４最主要的功能是与ＴＣＲ／ＣＤ３识别的ＭＨＣⅡ类分子表面的配体相互作用。ＣＤ４尚与ＴＣＲ／ＣＤ３呈物理相关，在ＭＨＣ Ⅱ类基因产物的调节下，引起强烈的Ｔ细胞激活信号。应用ａｎｔｉ－ＣＤ４干扰抗原识别及其对Ｔ细胞的激活而抑制ＣＤ４￣＋Ｔ细胞的功能，或者是通过诱导细胞毒效应、干扰细胞粘附以及通过对细胞的调理作用和细胞之间的相互作用，从体内清除ＣＤ４￣＋Ｔ细胞，或使Ｔ细胞在体内重新分布，此乃ａｎｔｉ－ＣＤ４治疗的关键。
Application of anti-CD4 antibody (anti-CD4) to induce transplant tolerance, treatment of autoimmune diseases has drawn people’s attention. The most important function of CD4 is to interact with ligands on the surface of MHC class II molecules recognized by TCR / CD3. CD4 is still physically related to TCR / CD3, causing a strong T-cell activation signal under the regulation of MHC class II gene products. Anti-CD4 interference antigen recognition and its activation of T cells to inhibit CD4 ~ + T cell function, either by inducing cytotoxic effects, interfering with cell adhesion and through the role of cells and the interaction between the cells, Removal of CD4 ~ + T cells from the body or redistribution of T cells in vivo is key to anti-CD4 treatment.