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目的:探究尿酸(UA)、B型脑钠肽(BNP)对急性心肌梗死患者预后的评估价值。方法:选择2015年2月至2017年2月湛江市中心人民医院的122例急性心肌梗死患者为观察组,并选择同期于本院接受健康体检的80例健康者。分别在入院后1d、3d、7d、15d行血清UA及BNP检测,对照组仅行1次检测。对入院不同时间的患者血清UA、BNP水平变化进行比较。结果:观察组的血UA为(371.5±69.4)μmol·L~(-1),BNP为(346.2±82.5)pg·mL~(-1)均显著高于对照组,差异具有统计学意义(P<0.05);经随访观察组中111例为存活,11例为死亡;存活组在入院后3d血UA及BNP水平达到高峰;死亡组在入院后7d血UA及BNP水平达到高峰,且入院后1d、3d、7d、15d存活组血UA及BNP水平均显著低于死亡组(P<0.05)。结论:对于急性心肌梗死患者,及时检测血UA、BNP水平异常变化并采取相应治疗措施,可有效改善预后。
Objective: To investigate the prognostic value of uric acid (UA) and brain natriuretic peptide (BNP) in patients with acute myocardial infarction. Methods: A total of 122 acute myocardial infarction patients in Zhanjiang Central People’s Hospital from February 2015 to February 2017 were selected as observation group and 80 healthy subjects undergoing physical examination in our hospital during the same period. Serum UA and BNP were detected on the 1st, 3rd, 7th and 15th day after admission, while the control group only tested once. Changes of serum UA and BNP levels in patients admitted to hospital at different times were compared. Results: The blood UA was (371.5 ± 69.4) μmol·L -1 and BNP was (346.2 ± 82.5) pg · mL -1 in the observation group, which were significantly higher than those in the control group P <0.05). In the follow-up observation group, 111 cases survived and 11 died. The levels of serum UA and BNP peaked at 3 days after admission in the survival group. The levels of blood UA and BNP peaked at 7 days after admission, The levels of serum UA and BNP in the surviving group were significantly lower than those in the deceased group on the 1st, 3rd, 7th and 15th day (P <0.05). Conclusion: In patients with acute myocardial infarction, timely detection of abnormal changes of blood UA and BNP levels and take appropriate treatment measures, can effectively improve the prognosis.