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目的：对比不同无创正压通气模式治疗心源性肺水肿的临床疗效及其对心肌酶学的影响。方法：将广东省韶关市第一人民医院急诊科和ICU2011年12月－2014年12月收治的心源性肺水肿患者120例随机分为观察组和对照组各60例，对照组采用持续气道内正压通气（CPAP）治疗，观察组采用双水平气道正压通气（BiPAP）治疗，比较两组疗效及心肌酶学。结果：观察组与对照组的总有效率无明显差异（90．0％ vs 86．7％，P＞0．05）。治疗后两组CK和CK－MB均显著高于治疗前（P＜0．05），但治疗后两组CK和CK－MB无明显差异（P＞0．05）。结论：对心源性肺水肿进行无创持续气道内正压通气和双水平气道正压通气模式治疗，均能够取得好疗效，但需监测心肌酶学的变化。“,”Objective:To compare the clinical efficacy of different noninvasive positive pressure ventilation in the treatment of cardiogenic pulmonary edema and the impact of enzymology. Methods:120 patients with cardiogenic pulmonary edema were randomly divided into the observation group and the control group,and each group was 60 cases in the department of emergency and ICU from Dec 2011 to Dec 2014. Control group was used continuous positive airway pressure (CPAP) therapy, while observation group was used Bi-level positive airway pressure (BiPAP) therapy. The clinical efficacy and the impact of enzymology were compared between the two groups. Results:The total effective rate in the observation group and control group was not significant difference (90.0% vs 86.7%,P>0.05). Compared to before treatment,CK and CK-MB were significantly higher after the treatment in both groups (P0.05). Conclusion: For patients with cardiogenic pulmonary edema as soon as possible the need for non-invasive positive pressure ventilation therapy,CPAP and BiPAP modes are able to achieve better results, but need to monitor cardiac function enzymatic changes.