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目的探讨HIV/AIDS者幽门螺杆菌(Hp)感染情况,并对相关因素进行分析。方法对151例有消化道症状的患者(其中HIV/AIDS组122例,对照组29例)行胃镜检查,并对活检黏膜行快速尿素酶及病理切片Warthin-Starry银染检测Hp感染情况。结果HIV/AIDS组消化道症状大多缺乏特异性,其中腹泻及吞咽困难或吞咽疼痛症状多于对照组(P<0.05)。HIV/AIDS组的Hp检出率22.1%(27/122),低于对照组的44.8%(13/29),(P<0.05)。其中,CD4<2.0×108/L的HIV/ AIDS者Hp检出率为14.0%(8/57),显著低于对照组(P<0.01)。HIV/AIDS组消化性溃疡检出率为4.1%(5/122),显著低于对照组的20.7%(6/29),(P<0.01)。结论HIV/AIDS组Hp感染率低于普通人群患者,原因可能与CD4细胞计数低下有关。
Objective To investigate the prevalence of Helicobacter pylori (Hp) in HIV / AIDS and analyze the related factors. Methods Gastroscopy was performed in 151 patients with gastrointestinal symptoms (including 122 HIV / AIDS patients and 29 control patients), and Hp infection was detected by biopsy mucosa with rapid urease and Warthin-Starry silver staining. Results Most of the gastrointestinal symptoms in HIV / AIDS group were lack of specificity. Diarrhea, dysphagia or swallowing pain symptoms were more than those in control group (P <0.05). The detection rate of Hp in HIV / AIDS group was 22.1% (27/122), which was lower than 44.8% (13/29) in control group (P <0.05). Among them, the detection rate of Hp in HIV / AIDS patients with CD4 <2.0 × 108 / L was 14.0% (8/57), which was significantly lower than that in the control group (P <0.01). The detection rate of peptic ulcer in HIV / AIDS group was 4.1% (5/122), significantly lower than that in control group (20.7%, 6/29) (P <0.01). Conclusion The prevalence of Hp infection in HIV / AIDS group is lower than that in the general population, probably due to the low CD4 cell count.