我国特有的新型光疗药物竹红菌素对细胞的光动力作用的“靶体”是细胞膜,它造成细胞膜蛋白中巯基含量大大降低,但是这一作用机制尚不清楚,刘卫和我们的工作,已表明在弱碱性条件下,竹红菌甲素和乙素(Hypocrel1in B,简称HB)都很容易地和巯基乙醇、巯基乙酸、正辛硫醇等巯基化合物发生取代反应,而造成巯基含量大大降低,有理由设想,这一作用 China’s unique new phototherapy drugs Hypocrellin photodynamic effect on the cell “target” is the cell membrane, which causes the membrane protein in the sulfhydryl content is greatly reduced, but the mechanism of this action is not clear, Liu Wei and our work, It has been shown that hypocrellin A and H (Hypocrelinin B, HB) can easily react with mercapto compounds such as mercaptoethanol, thioglycolic acid and n-octanethiol under mildly alkaline conditions to cause sulfhydryl content Greatly reduce, reason to imagine, this role