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本组10例均系门诊病人,男女各5例,14岁下3例,15～35岁7例。10例均因腹胀,食欲不振,恶心、呕吐服用胃复安、剂量为5～10mg/次,每日3次。在末次服药后8～72小时,出现急性锥体外系反应症状。表现为头向后仰、颈僵或歪向1侧8例。双眼上视、斜视9例。舌后抽感、构音不清,强制张口,不能吞咽及流涎7例。伸舌不能或偏向一侧5例。肢体及躯干扭屈6例,肢体僵直、行走困难5例。精神紧张10例,其中3例为儿童伴哭喊。每次发作持续5～10分钟,间隔20～30分钟。发作时神志清楚,7例做脑电图5例示正常,2例径度异常。10例来诊前有6例按癔病治疗,5例肌注安定10mg半小时均无效。就诊时肌注东莨菪碱0.3mg,在15～30分钟内症状消失。
The group of 10 patients were outpatients, 5 were male and female, 3 under 14 years old, 15 to 35 years old in 7 cases. 10 cases were due to abdominal distension, loss of appetite, nausea, vomiting stomach metformin, a dose of 5 ~ 10mg / times, 3 times a day. In the last dose of 8 to 72 hours after the onset of symptoms of acute extrapyramidal reactions. Performance for the head backwards, stiff neck or crooked side of the 8 cases. Eyes, strabismus in 9 cases. After the tongue pumping sense, unclear articulation, mandatory mouth, can not swallow and salivation in 7 cases. Extension of the tongue can not or side to side 5 cases. Body and torso deformity in 6 cases, limb stiffness, walking difficulties in 5 cases. Mental stress in 10 cases, of which 3 cases of crying with children. Each episode lasts 5 to 10 minutes, 20 to 30 minutes apart. Conscious when the attack, 7 cases of EEG 5 cases showed normal, 2 cases of abnormal diameter. There were 6 cases of rickets treated in 10 cases before treatment, and 5 cases of intramuscular injection of diazepam for 10 and a half hours were ineffective. When treated with intramuscular scopolamine 0.3mg, 15 to 30 minutes the symptoms disappear.