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目的探讨胃溃疡患者应用兰索拉唑治疗前、后血浆丙二醛(malondialdehyde,MDA)、抗氧化酶超氧化物歧化酶(superoxide dismutase,SOD)及一氧化氮(nitrogen,NO)水平变化及意义。方法胃溃疡患者150例,随机分为兰索拉唑组75例和奥美拉唑组75例,2组分别连续应用兰索拉唑+阿莫西林+甲硝唑、奥美拉唑+阿莫西林+甲硝唑治疗30d。分别于治疗前、后检测3组血浆MDA、SOD、NO水平,并与75例体检健康者(对照组)进行比较。结果治疗前,兰索拉唑组、奥美拉唑组血浆SOD[(50.99±7.65)、(51.02±9.03)u/L]、MDA[(7.44±1.28)、(7.50±1.17)μmol/L]水平均高于对照组[(30.62±6.07)u/L、(3.75±1.13)μmol/L],NO[(50.36±9.12)、(50.13±8.87)μmol/L]水平低于对照组[(69.05±8.89)μmol/L](P<0.05),兰索拉唑组、奥美拉唑组血浆SOD、MDA、NO水平比较差异无统计学意义(P>0.05);治疗30d后,兰索拉唑组、奥美拉唑组血浆SOD[(32.58±2.47)、(45.69±7.88)u/L]、MDA[(4.15±1.21)、(6.89±2.47)μmol/L]水平均较治疗前下降,NO[(68.71±7.49)、(55.69±9.18)μmol/L]水平均较治疗前增高(P<0.05);兰索拉唑组各指标改善优于奥美拉唑组(P<0.05)。结论胃溃疡患者应用兰索拉唑治疗在改善血浆因子水平上优于奥美拉唑。
Objective To investigate the changes of plasma malondialdehyde (MDA), superoxide dismutase (SOD) and nitrogen (NO) levels before and after treatment with lansoprazole in patients with gastric ulcer. significance. Methods 150 cases of gastric ulcer patients were randomly divided into lansoprazole group 75 cases and omeprazole group 75 cases, two groups were consecutive application of lansoprazole + amoxicillin + metronidazole, omeprazole + Moxillin + metronidazole treatment for 30 days. The plasma levels of MDA, SOD and NO were measured before and after treatment, and compared with 75 healthy controls (control group). Results Before treatment, the plasma levels of SOD [(50.99 ± 7.65), (51.02 ± 9.03) u / L], MDA [(7.44 ± 1.28), (7.50 ± 1.17) μmol / L in lansoprazole group and omeprazole group, ] Were significantly higher than those in the control group [(30.62 ± 6.07) u / L, (3.75 ± 1.13) μmol / L, NO [50.36 ± 9.12] and (50.13 ± 8.87) μmol / (69.05 ± 8.89) μmol / L] (P <0.05). The levels of plasma SOD, MDA and NO in lansoprazole group and omeprazole group had no significant difference (P> 0.05) The plasma levels of SOD [(32.58 ± 2.47) and (45.69 ± 7.88) u / L] and MDA [(4.15 ± 1.21) and (6.89 ± 2.47) μmol / L] (68.71 ± 7.49), (55.69 ± 9.18) μmol / L] were significantly higher than those before treatment (P <0.05), and those in lansoprazole group were superior to those in omeprazole group (P < 0.05). Conclusions Lansoprazole treatment of patients with gastric ulcer is better than omeprazole in improving plasma factor level.