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目的观察长期吸烟对血管内皮功能的影响。方法采用超声肱动脉内径测量法，观察了30例长期吸烟者左上肢肱动脉内径对反应性充血和含服消心痛的反应性变化，以另外30例非吸烟正常人作为对照组。结果在基础状态下，吸烟组和非吸烟组肱动脉内径基本相同（P＞0.05；反应性充血后，吸烟组肱动脉内径变化明显小于对照组（114±1.7）%比（19.1±1.6）％，P＜0．05，含服消心痛后两组肱动脉内径变化基本相同（19．4±1.8）％比（21．6±2．1）％，P＞0.05。结论长期吸烟对人体血管内皮依赖性舒张功能具有明显损害，而对非内皮依赖性舒张功能影响不大，这种血管内皮损伤变化在心血管病的发病中的作用尚待进一步研究。
Objective To observe the effect of long-term smoking on vascular endothelial function. Methods Ultrasound brachial artery diameter measurement was used to observe the changes of the brachial artery diameter of the left upper extremity in 30 long-term smokers. The other 30 non-smokers were used as the control group. Results In the basal state, the diameter of brachial artery was the same in smoking group and non-smoking group (P> 0.05). After reactive hyperemia, the diameter of brachial artery in smoking group was significantly lower than that in control group (114 ± 1.7)% (19.1 ± 1.6)% (P <0.05). The internal diameter of the brachial artery in the two groups was basically the same (19.4 ± 1.8)% vs (21.6 ± 2.1)%, P> 0.05, Endothelium-dependent vasodilation has obvious damage, but not endothelium-dependent diastolic function has little effect on vascular endothelial injury in the pathogenesis of cardiovascular disease remains to be further studied.