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目的:探讨长沙市肥胖小学生血清瘦素(leptin)水平的变化及其影响因素。方法:长沙市5所小学7～12周岁学龄儿童中随机抽取单纯性肥胖儿童119名和正常体重儿童103名,分别测定腰围(WC),臀围,腰臀比(WHR),双能X线骨密度仪(DEXA)测量体脂百分比(%BF),并检测血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)和空腹胰岛素(FINS),计算稳态模型胰岛素抵抗指数(HOMA-IR),ELISA法测血清瘦素(Leptin)。结果:肥胖小学生血清瘦素水平显著高于正常儿童(P<0.01),肥胖小学生瘦素水平与BMI、WC、WHR、%BF、TG、LDL-C呈明显正相关,与HDL-C呈明显负相关,多元逐步回归分析表明FINS、HOMA-IR、BMI、TG、LDL-C及%BF是肥胖儿童血清瘦素水平的主要相关因素。结论:长沙市肥胖小学生血清瘦素水平升高且与体脂、胰岛素抵抗和血脂明显相关。
Objective: To investigate the changes of serum leptin levels and its influencing factors in obese pupils in Changsha City. Methods: 119 children with simple obesity and 103 children with normal weight were randomly selected from 5 primary school children aged from 7 to 12 in Changsha City. The waist circumference (WC), hip circumference, waist - hip ratio (WHR), dual energy X - ray Body fat percentage (% BF) was measured with a densitometer (DEXA) and serum triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol Fasting blood glucose (FBG) and fasting insulin (FINS) were calculated. HOMA-IR was calculated and Leptin was detected by ELISA. Results: Serum leptin levels of obese pupils were significantly higher than those of normal children (P <0.01). Leptin levels of obese pupils were positively correlated with BMI, WC, WHR,% BF, TG and LDL- Negative correlation and multiple stepwise regression analysis showed that FINS, HOMA-IR, BMI, TG, LDL-C and% BF were the main relevant factors of serum leptin levels in obese children. Conclusions: Serum leptin levels are elevated in obese pupils in Changsha City and are significantly correlated with body fat, insulin resistance and blood lipids.