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大白静脉内接种子孢子(SP)后24小时(h),灌服硝喹醋酸盐(1mg/kg)单次剂量,在不同时间活检或活杀动物,检查红外期原虫,其中部分动物并作血检,观察原虫血症。结果。①接种SP后48h,给药组动物肝组织内原虫密度较低,退变原虫发生率高;54、65和72h红外期原虫核大小不等,与原虫体积不相称,核团块大小不一,数量增多;并可见到白细胞浸润的变性原虫;在接种SP后72h内,均未发现成熟红外期原虫。②给药组8只动物中仅一只血检阳性。但密度低,虫现前斯长。实验结果表明硝喹对约氏疟原虫具有病因性预防效果,并提示硝喹可能通过抑制核分裂而影响红外期原虫的发育。
24 hours after inoculation of sporozoites (SP) in large white veins (SP), a single dose of doxorubicin (1 mg / kg) was orally administered. Animals were biopsied or killed at different times. For blood tests to observe parasitemia. result. (1) At 48h after inoculation, the protozoa density of liver tissue in the treated group was lower and the incidence of protozoal degenerative worms was higher; in the 54th, 65th and 72th hours, the protozoa nuclear size was not equal to that of the protozoa and the nucleus size was different , The number increased; and can see the leukocyte infiltration of degenerate protozoa; within 72h after inoculation SP, were not found mature IR protozoa. ② Only 8 of the 8 animals in the administration group were positive for blood tests. But the density is low, the worm is long ago. The experimental results showed that quinine had etiologic preventive effect on Plasmodium yoelii and suggested that quinalinkine might affect the development of protozoan in the IR stage by inhibiting mitosis.