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目的：探讨模拟坦克射击后舱内污染气体ＳＯ２ 、ＮＯ２ 对豚鼠气道功能的影响。方法：动物行人工通气，吸入三组不同浓度混合气体（Ａ 组：ＳＯ２５ ｐｐｍ ＮＯ２１．５ ｐｐｍ ；Ｂ组：ＳＯ２１０ ｐｐｍ ＮＯ２３ ｐｐｍ ；Ｃ组：ＳＯ２１５ ｐｐｍ ＮＯ２５ ｐｐｍ） 持续１５ ｍｉｎ，于吸入前后测定气道内压（ＩＰ），并行组胺气道激发试验。测定ＢＡＬ细胞成份变化及行病理检查。结果：吸入混合气体后三组ＩＰ均有升高，但与吸入空气时相比ＩＰ无显著性差异（ Ｐ＞０．０５）。组织胺激发后ＰＣ２０ 值与对照组相比，三组均差异显著（Ｐ＜ ０．０５） 。且ＢＡＬ中性粒细胞数增加。结论：短时吸入ＳＯ２、ＮＯ２ 可使豚鼠气道反应性增高，导致气道炎症产生。
Objective: To investigate the effects of SO2 and NO2, a pollutant gas in cabin, on the airway function of guinea pigs after simulated tank fire. Methods: The animals were ventilated by hand and inhaled three different concentrations of mixed gas (group A: SO25 ppm NO21.5 ppm; group B: SO210 ppm NO23 ppm; group C: SO215 ppm NO25 ppm) for 15 min before and after inhalation Road pressure (IP), parallel histamine airway stimulation test. Determination of BAL cell changes in composition and pathological examination. Results: IP was increased in all three groups after inhalation of mixed gas, but there was no significant difference in IP compared with that in inhaled air (P> 0.05). Compared with the control group, the PC20 values of histamine excited group were all significantly different (P <0.05). And BAL neutrophils increased. Conclusion: Short-term inhalation of SO2 and NO2 can increase the airway responsiveness of guinea pigs and lead to airway inflammation.