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免疫反应的产生首先是抗原提呈细胞(APC)捕获抗原,经其加工处理后将其抗原信息传递给T、B细胞,从而引发一系列的特异性免疫反应。APC包括树突状细胞(DC)、巨噬细胞、B细胞等,其中DC的功能最强,它最大特点是能够激发处女T细胞增殖。自从1973年Steinman和Cohn在小鼠脾脏中发现DC以来,DC的研究一直受到免疫学界的关注并取得许多重要成果。 1 DC的一般特性及表型目前认为,DC是具有典型树突状形态、膜表面高表达主要组织相容性复合物(MHC)类分子、能移行至淋巴器官
The immune response is generated by antigen-presenting cells (APC) capture antigen, the processing of its antigen information to T, B cells, which triggered a series of specific immune response. APC includes dendritic cells (DCs), macrophages, B cells, etc., of which DC is the most powerful, its most prominent feature is the ability to stimulate virgen T cell proliferation. Since the discovery of DCs by Steinman and Cohn in mouse spleens in 1973, the study of DC has received much attention from the immunology community and many important achievements have been made. DC general characteristics and phenotype Currently considered DC is a typical dendritic morphology, the membrane surface expression of major histocompatibility complex (MHC) molecules, can migrate to lymphoid organs