阿霉素(Doxorubicin,Adriamycin)是最有效的癌化疗药物之一。如同大多数化疗药物一样,阿霉素的急性剂量限制性毒性为骨髓抑制。其他付作用包括恶心、呕吐和脱发均是可逆的。阿霉素尚有一种蒽环素类(anthracyclines)所特有的慢性毒性:心脏毒性。目前尚无这一付作用是可逆性的依据。作者成功地应用此药联合其他药物和其他方法治疗癌时,这一不可逆和延迟的毒性反应显得特别重要。阿霉素的心脏毒性表现为急性、短暂的心电图改变——常为良性心律失常,以及后期的心肌病二种。心律失常很少有临床意义,与心 Doxorubicin (Adriamycin) is one of the most effective cancer chemotherapy drugs. Like most chemotherapeutic drugs, the acute dose-limiting toxicity of doxorubicin is bone marrow suppression. Other side effects including nausea, vomiting and hair loss are all reversible. Adriamycin also has a chronic toxicity characteristic of anthracyclines: cardiotoxicity. At present, no such effect is the basis for reversibility. This irreversible and delayed toxicity was particularly important when the authors successfully used this drug in combination with other drugs and other methods to treat cancer. Cardiotoxicity of doxorubicin is manifested as acute, transient electrocardiographic changes - often benign arrhythmias, and late cardiomyopathy. Arrhythmias have little clinical significance and heart