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为了确认草药对乙型肝炎病毒(HBV)的作用,用151种韩国草药提取物,进行了对乙型肝炎病毒表面抗原(HBsAg)结合作用及对HBV DNA聚合酶活性影响的研究。结果,有33种提取物可以和HBsAg~+血清发生阳性沉淀反应,其中15种提取物可以特早性结合血清中HBsAg及重组HBsAg(Hepavax~R);9种提取物对抗-HBsAg抗体与Hepavax~R HBsAg的结合反应的抑制作用在80％以上。另外,15种提取物中,有9种提取均对HBV DNA聚合酶活性的抑制作用达25％以上,并且还明显地刺激肿瘤坏死因子TNF的产生。没有一种提取物使健康大鼠的肝功能参数发生变化。
In order to confirm the effect of herbal medicine on hepatitis B virus (HBV), 151 kinds of Korean herbal extracts were used to study the binding of hepatitis B virus surface antigen (HBsAg) and the effect of HBV DNA polymerase activity. As a result, 33 extracts could positively react with HBsAg~+ sera. Among them, 15 extracts can specifically bind serum HBsAg and recombinant HBsAg (Hepavax~R); 9 extracts against anti-HBsAg antibody and Hepavax The inhibitory effect of ~R HBsAg binding is above 80%. In addition, nine of the 15 extracts had inhibitory effects on the HBV DNA polymerase activity by more than 25%, and also significantly stimulated the production of tumor necrosis factor TNF. None of the extracts changed the parameters of liver function in healthy rats.