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目的:探讨贫血对晚期非小细胞肺癌患者化疗效果的影响。方法:选取120例晚期非小细胞肺癌患者作为研究对象,对其血红蛋白水平变化予以回顾性分析,探讨贫血的发生的危险因素,分析其与化疗疗效的关系,评价其影响。结果:所有患者在化疗2个周期以后,贫血发生率均明显提升,(80.03%VS56.67%,P<0.01),贫血严重程度随周期增加而加重。经多因素Logistic回归分析证实,年龄、临床分期、PS评分、白蛋白水平是引发癌性贫血的危险因素,化疗前后患者发生贫血,均显著降低了化疗疗效。结论:贫血对晚期非小细胞肺癌患者化疗效果的影响较大,需予以预防及控制。
Objective: To investigate the effect of anemia on chemotherapy in patients with advanced non-small cell lung cancer. Methods: One hundred and twenty patients with advanced non-small cell lung cancer were enrolled in this study. The changes of hemoglobin level were retrospectively analyzed. The risk factors of anemia were analyzed. The relationship between them and the curative effect of chemotherapy was analyzed and their effects were evaluated. Results: After 2 cycles of chemotherapy, the incidence of anemia was significantly increased in all patients (80.03% vs 56.67%, P <0.01). The severity of anemia increased with the increase of cycles. Multivariate Logistic regression analysis confirmed that age, clinical stage, PS score, albumin level are the risk factors of cancer-causing anemia, patients with anemia before and after chemotherapy, significantly reduced the efficacy of chemotherapy. Conclusion: Anemia in patients with advanced non-small cell lung cancer chemotherapy has a greater impact, need to be prevented and controlled.