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目的比较苏州地区新甲型H1N1流感病毒与呼吸道合胞病毒(RSV)引起小儿重症感染的特点。方法比较分析24例甲型H1N1流感患儿(甲型H1N1组)与42例的RSV感染患儿(RSV组)的临床特征及其预后。结果与RSV组比较,甲型H1N1组平均年龄大,危重病例评分(PCIS)低,死亡风险评分(PRISMⅢ)高,住院时间和机械通气时间长,发热、急性呼吸窘迫综合征发生率高,喘息发生率低,肌钙蛋白、谷氨酸氨基转移酶、乳酸脱氢酶和C反应蛋白异常升高比例高(P<0.05)。甲型H1N1组影像学主要表现为两肺大范围实变影,肺气漏征象多见;RSV组主要表现为两肺门纹理改变及弥漫气肿。结论了解上述不同特点有利于儿童甲型H1N1流感和RSV感染的鉴别和早期进行针对性治疗。
Objective To compare the characteristics of severe infection in children caused by new influenza A (H1N1) and respiratory syncytial virus (RSV) in Suzhou. Methods The clinical features and prognosis of 24 children with RSV infection (group A H1N1) and 42 children with RSV infection (group RSV) were compared and analyzed. Results Compared with the RSV group, the average age of the H1N1 group was significantly lower, the PCIS score was lower, the risk of PRISM Ⅲ was higher, the duration of hospitalization and mechanical ventilation were longer, the incidence of fever and ARDS was higher, Low incidence, abnormal troponin, glutamate aminotransferase, lactate dehydrogenase and C-reactive protein increased (P <0.05). A group of H1N1 imaging mainly manifested as a wide range of solid images of both lungs, pulmonary airway signs are more common; RSV group mainly for the two hilar changes in texture and diffuse emphysema. Conclusion Understanding the above characteristics is beneficial to the identification of children with influenza A (H1N1) and RSV infection and early targeted therapy.