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目的:探讨血管内皮生长因子(VEGF)和增殖细胞核抗原(PCNA)在骨肉瘤组织中的表达及其与微血管密度(MVD)、预后的关系。方法:用免疫组织化学法检测64例骨肉瘤组织中VEGF、PCNA的表达和MVD。结果:VEGF阳性表达主要在胞浆,PCNA的阳性表达主要在胞核。VEGF、PCNA表达与MVD存在显著关联(P<0.05),与骨肉瘤转移和5年生存率有显著关联性(P<0.05)。VEGF表达与PCNA表达密切相关(P<0.05)。结论:VEGF和PCNA指标可作为判断骨肉瘤预后的重要指标。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in osteosarcoma and its relationship with microvessel density (MVD) and prognosis. Methods: The expression of VEGF, PCNA and MVD in 64 osteosarcoma tissues were detected by immunohistochemistry. Results: The positive expression of VEGF mainly in the cytoplasm, PCNA positive expression mainly in the nucleus. There was a significant correlation between the expression of VEGF and PCNA and MVD (P <0.05), and metastasis to osteosarcoma and 5-year survival rate (P <0.05). The expression of VEGF was closely related to the expression of PCNA (P <0.05). Conclusion: VEGF and PCNA indicators can be used as an important indicator to determine the prognosis of osteosarcoma.