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目的 探讨母婴ＡＢＯ／Ｒｈ 血型不合产前诊断的有效策略。方法 对ＡＢＯ／Ｒｈ 血型不合孕妇，在孕期进行免疫抗体动态监测，并采用基因定型技术产前鉴定Ｒｈ 基因型。结果 ５ 例Ｒｈ 阴性具有不良孕产史孕妇在本方案中及时得到有效处理，并对她们用基因定型技术进行分析；ＡＢＯ系统新生儿溶血病占高胆红素血症患儿的１２－６ ％ ，Ｒｈ 系统ＨＤＮ 占其中的４－９‰；本文还得到２２１９ 例孕妇产前血清ＩｇＧ抗Ａ（Ｂ） 效价分布比率概况。结论 制定产前监测和控制ＨＤＮ 方案，及时检测引起ＨＤＮ 的免疫抗体，采取适当措施可减少对新生儿的危害，ＩｇＧ 型抗体效价的高低与新生儿溶血病发生率成正比关系，基因定型分析在产前ＨＤＮ 诊断中将有巨大潜力。
Objective To explore the effective strategy of prenatal diagnosis of maternal-ABO / Rh incompatibility. Methods The pregnant women with ABO / Rh blood group were immunized with immune antibody during pregnancy. Rh genotype was determined prenatally by genotyping technique. Results Five cases of Rh-negative pregnant women with adverse pregnancy history were effectively treated in this protocol and their genotypes were analyzed. ABO neonatal hemolytic disease accounted for 12-6% of children with hyperbilirubinemia, , Rh system HDN accounted for 4-9 ‰; this article also obtained 2219 cases of pregnant women prenatal serum IgG anti-A (B) titers distribution profile. Conclusions The prenatal monitoring and control of HDN program to develop and timely detection of HDN-causing immune antibodies, take appropriate measures to reduce the risk of neonatal, IgG antibody titer is directly proportional to the incidence of hemolytic disease of newborns, genotyping analysis There will be great potential in prenatal HDN diagnosis.