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目的探讨分析来氟米特治疗狼疮肾炎临床疗效。方法本院2011年8月~2012年8月收治的20例系统性红斑狼疮合并肾炎的患者,采用氟米特对其进行治疗,观察其治疗前后系统性红斑狼疮活动指数(SLEDAI)评分及临床、免疫指标;治疗前后进行肾脏活检,观察其病理变化。结果治疗1个月后,患者各项活动指标均有所改善,3个月后病情缓解明显,一年后患者病情明显改善并且维持稳定,SLEDAI评分明显改善,肾脏活检患者有6例发生了病理转型,由重转轻,其余病情均表现出稳定好转,无发现有肾复发病例。结论氟米特治疗狼疮肾炎临床疗效显著,毒副作用较小,是一种安全有效且经济的免疫抑制剂。
Objective To investigate the clinical efficacy of leflunomide in the treatment of lupus nephritis. Methods Twenty patients with systemic lupus erythematosus and nephritis treated in our hospital from August 2011 to August 2012 were treated with leflunomide and the SLEDA scores before and after treatment were observed. , Immune indicators; kidney biopsy before and after treatment to observe the pathological changes. Results After 1 month of treatment, all the patients’ activity indexes improved. After 3 months, the condition was relieved obviously. After one year, the patient’s condition improved obviously and remained stable. The SLEDAI score improved obviously. There were 6 cases of renal biopsy Transformation, from heavy to light, the rest of the disease showed a stable improvement, no cases of renal recurrence found. Conclusion It is a safe, effective and economical immunosuppressant to treat patients with lupus nephritis with significant clinical efficacy and less side effects.