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应用免疫组织化学ＳＡＢＣ法对５２ 例良性多形性腺瘤（ＢＰＡ）、１３ 例恶性多形性腺瘤（ＭＰＡ）患者及６ 例正常涎腺（对照组）者涎腺组织中的Ｃ－ｅｒｂＢ－２Ｐ１８５ 蛋白进行检测，结果：Ｃ－ｅｒｂＢ－２Ｐ１８５ 蛋白阳性表达率在对照组为０，ＢＰＡ组为６９．２３％ ，ＭＰＡ组为９２．３１％ ；ＢＰＡ组、ＭＰＡ组与对照组比较有极显著差异（Ｐ＜ ０．００１），ＢＰＡ组与ＭＰＡ组之间亦有显著差异（Ｐ＜ ０．０１）。提示Ｃ－ｅｒｂＢ－２Ｐ１８５ 蛋白在涎腺多形性腺瘤的发生、发展过程中起重要作用。
The immunohistochemistry SABC method was used to detect C-erbB-2P185 in 52 cases of benign pleomorphic adenoma (BPA), 13 cases of malignant pleomorphic adenoma (MPA) and 6 cases of normal parotid gland (control group). Proteins were detected. Results: The positive expression rate of C-erbB-2P185 protein was 0 in the control group, 69.23% in the BPA group, and 92.31% in the MPA group. There was a significant difference between the BPA group and the MPA group and the control group. (P<0.001), there was also a significant difference between BPA group and MPA group (P<0.01). It suggests that C-erbB-2P185 protein plays an important role in the occurrence and development of parotid pleomorphic adenoma.